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基于等离子体蛋白质组学的生物标志物用于预测重症COVID-19中介质干细胞治疗的反应

Tian-Tian Li¹, Wei-Qi Yao^2,3, Hai-Bo Dong⁴

¹Senior Department of Infectious Diseases, The Fifth Medical Centre of PLA General Hospital, National Clinical Research Center for Infectious Diseases, No.100 Western 4th Ring Road, Beijing, 100039, People's Republic of China.

Stem cell research & therapy

|December 10, 2023

概括

这项研究确定了预测重症COVID-19患者对Mesenchymal干细胞 (MSC) 治疗的反应的关键血蛋白. 这些生物标志物可以帮助优化MSC治疗决策,以获得更好的患者结果.

科学领域:

蛋白质组学是指蛋白质组学.
免疫学免疫学免疫学
关键护理医学关键护理医学

背景情况:

严重的COVID-19 presents一个显著的临床挑战.
中介细胞干细胞 (MSC) 疗法正在针对严重的COVID-19进行探索.
预测MSC治疗反应对于治疗优化至关重要.

研究的目的:

确定可预测严重COVID-19中MSC治疗反应的血蛋白质生物标志物.
为了优化患者选择MSC治疗.

主要方法:

从58名严重的COVID-19患者 (35名反应者,23名非反应者) 的血蛋白质组资料分析.
用于血分析的数据独立获取 (DIA) 蛋白质组学.
应用多变量逻辑回归来识别预测生物标志物.

主要成果:

在血中发现了1101种蛋白质.
与非响应者相比,响应者显示出不同的蛋白质组概况.
一种后勤回归模型将较低的DDX55,AGRG6,PICAL,ANXA1和较高的CTRB1确定为反应的预测因子 (训练集中的AUC为0.910).

结论:

血中DDX55,AGRG6,PICAL,CTRB1和ANXA1的基线水平预测了MSC治疗的反应性.
这些蛋白质生物标志物可以指导临床决策,在严重的COVID-19中启动MSC治疗.

关键词:

在 COVID-19 疫情中,介质细胞干细胞介质细胞干细胞预测模型是一个预测模型.蛋白质组学是指蛋白质组学.

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