素及其衍生物的新临床应用前景:范围审查
Yangmu Huang1,2, Yang Yang3, Guangqi Liu4
1School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China. ymhuang@bjmu.edu.cn.
Infectious diseases of poverty
|December 10, 2023
概括
素衍生物显示出作为对瘤,寄生虫,炎症和皮肤疾病的安全和有效治疗的希望. 建议进行进一步的临床试验,特别是针对抗病毒应用.
科学领域:
- 药理学和热带医学 热带医学
- 药物发现和开发 药物发现和开发
背景情况:
- 素及其衍生物已经证明了除疟疾之外的潜在治疗应用,包括对抗寄生虫,病毒,瘤,炎症和皮肤疾病.
- 本综述重点关注素衍生物的临床研究,不包括它们的抗疟疾用途,以确定未来的发展优先事项.
研究的目的:
- 系统地审查和分析用于非疟疾治疗应用的素衍生物的临床研究.
- 识别知识缺口和未来研发的潜在优先领域.
主要方法:
- 在多个数据库 (PubMed/MEDLINE,Embase,WanFang等) 进行了全面的文献搜索. 在2021年10月28日之前发表的英语和中文文章.
- 根据预先定义的标准选择了研究,并提取和分析了有关地区,疾病,结果和时间的数据.
主要成果:
- 77项研究涵盖了抗寄生虫,抗瘤,抗炎,抗病毒和皮肤病治疗. 抗寄生虫研究是广泛的,而抗病毒研究是有限的,主要是在第一阶段.
- 大多数研究来自亚洲 (60%) 和非洲 (27%),而抗瘤研究在欧洲和美国更为普遍. 素衍生物通常表现出良好的安全性,很少出现严重的不良反应.
- 在抗寄生虫,抗瘤,抗炎症和皮肤病学应用方面注意到治疗效果,尽管对非疟疾寄生虫疾病的疗效仍在争论中.
结论:
- 素衍生物是开发针对瘤,寄生虫,炎症和皮肤疾病的新药的安全和有效候选者.
- 扩展的II/III期临床试验对于进一步评估素衍生物的抗病毒潜力至关重要.
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