咖啡和咖啡因摄入量降低了性结肠炎的风险:日本的一项病例对照研究
Keiko Tanaka1, Hitomi Okubo1, Yoshihiro Miyake1
1Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Toon, Japan.
咖啡和咖啡因消费可能会降低性结肠炎 (UC) 风险,特别是在日本人群中. 这项研究发现,较高的咖啡和碳酸饮料摄入量与较低的UC风险相关,而巧克力摄入量增加了UC风险.
科学领域:
- 胃肠病学 胃肠病学
- 营养流行病学 营养流行病学
- 环境健康 环境健康
背景情况:
- 饮食因素与性结肠炎 (UC) 发病因子有关,但确的证据仍然有限.
- 环境影响,包括饮食,对于理解UC发育至关重要.
- 调查特定的食物和饮料消费提供了关于UC风险因素的见解.
研究的目的:
- 调查咖啡,含咖啡因的饮料/食物和咖啡因总摄入量与患性结肠炎 (UC) 的风险之间的关联.
- 检查特定饮食因素和UC风险的剂量反应关系.
- 提供关于咖啡因和咖啡在日本人口中UC病因学中的作用的证据.
主要方法:
- 一项日本病例控制研究,涉及384例UC病例和665例对照.
- 半定量食品频率调查问卷评估咖啡,无咖啡因咖啡,茶,软饮料和巧克力的摄入量.
- 对许多共同变量进行统计调整,包括吸烟,酒精,BMI和营养摄入量.
主要成果:
- 较高的咖啡和碳酸软饮料消费量与UC风险有显著的反向关联 (分别P<0.0001和P=0.01).
- 增加巧克力零食的摄入量与UC的更高风险显著相关.
- 咖啡因总摄入量与UC风险相反相关 (OR 0.44;P<0.0001).
结论:
- 咖啡和咖啡因摄入量与性结肠炎 (UC) 的风险降低有关.
- 这些发现甚至适用于相对较低咖啡消费人口,如日本.
- 饮食模式,包括咖啡因摄入量,可能在UC预防中起到可改变的作用.
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