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Updated: Jul 8, 2025

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使用组合精细化策略和分子动力学,阐明 p53 适配体中的结构变异性.

Md Rimon Parves1,2,3, Maria J Solares1,2,4, William J Dearnaley1,2

  • 1Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.

Cancer biology & therapy
|December 11, 2023
PubMed
概括

新的计算方法揭示了野生类型p53 (瘤抑制剂) 的隐藏蛋白质构造. 这项研究确定了p53必不可少的灵活区域.

关键词:
瘤抑制蛋白质是一种瘤抑制蛋白质.低温电子显微镜 (EM) 的使用分子动力学分子动力学在 p53 里,p53 是一个 p53 号码.现实空间的精细化改进.模拟火的模拟火

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Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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