基原蛋白在表观遗传上调节三阴性乳腺癌细胞中的线粒相关 lncRNA MANCR

Kirsten M Tracy1, Shannon Prior2, Willem T Trowbridge1

  • 1Department of Biochemistry, University of Vermont Larner College of Medicine, Burlington, VT 05405.

概括

长非编码RNAMANCR对于三阴性乳腺癌 (TNBC) 细胞生存和基因组稳定性至关重要. 体蛋白质,特别是BRD4,通过对超级增强剂的表观遗传控制来调节MANCR表达.

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