自然活性化合物的研究进展改善了细胞功能,以减少糖尿病病中的蛋白尿症
Le Gong1, Rui Wang1, Xinyu Wang1
1School of Pharmacy, Shanxi Medical University, Taiyuan, China.
Renal failure
|December 11, 2023
概括
天然活性化合物 (NACs) 通过改善 podocyte 特定蛋白质 (PSPs) 和减少蛋白尿症,在治疗糖尿病病 (DKD) 中表现有前途. 关键化合物通过各种信号通路作用,保护功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 糖尿病病 (DKD) 是末期病的主要原因.
- 足细胞损伤和随后的蛋白尿是DKD进展的标志.
- 足细胞特异性蛋白 (PSP) 对于正常的脏过至关重要.
研究的目的:
- 探索自然活性化合物 (NAC) 改善DKD蛋白尿症的机制,重点关注PSP.
- 总结15个NAC对蛋白尿和PSP的影响.
- 阐明涉及NACs脏保护作用的信号通路.
主要方法:
- 审查和分类与蛋白尿和PSP功能相关的五个阶段的DKD.
- 15个NAC改善蛋白尿和改善PSP的机制的总结.
- 关于化合物的疗效和信号通路 (AMPK,TLR4,MAPK,NF-κB,PERK) 的体外和体内机械研究.
主要成果:
- 五种化合物 (阿斯特拉加索酸IV,利古斯特拉辛,柏柏林,埃莫丁,白醇) 通过AMPK信号传递显示脏受保护.
- 伊卡林和柏柏林通过TLR4信号传递起作用;希鲁丁和贝卡林通过MAPK信号传递起作用.
- 黄素和贝卡林涉及NF-κB信号传递;埃莫丁通过PERK信号传递. 13个PSP被分为五个功能组.
结论:
- 通过抗炎症,抗氧化应激和增强的自机制,NACs可以改善DKD.
- 足细胞亡主要与裂口隔膜PSP如尼夫林和Podocin有关.
- 了解NAC对PSP的影响为DKD提供了治疗潜力.
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