金字塔管完整性对皮质可塑性及其相关功能在患有多发性硬化症的患者中的重要性
Carolin Balloff1,2, Philipp Albrecht1,2, Arved-Sebastian Stucke1
1Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
Frontiers in neurology
|December 11, 2023
概括
由四脉冲刺激 (QPS) 引起的皮质可塑性在多发性硬化症 (MS) 亚型和健康对照中是相似的. 然而,可塑性与运动和认知功能只有在皮质脊髓管完好无损时才相关.
科学领域:
- 神经科学是一个神经科学.
- 神经康复疗法 神经康复疗法
- 临床神经学 临床神经学
背景情况:
- 由四脉冲刺激 (QPS) 诱导的皮质可塑性与复发性复发性硬化症 (RRMS) 中的认知功能有关.
- 之前的发现表明,与健康对照组 (HCs) 相比,RRMS中QPS诱导的可塑性被保留.
研究的目的:
- 在多发性硬化症 (MS) 亚型 (渐进性MS[PMS]和RRMS) 和HC中比较QPS诱导的可塑性.
- 探索QPS诱导的可塑性和MS患者的运动/认知性能之间的关系.
- 为了测试PMS与HC和RRMS相比减少可塑性的假设.
主要方法:
- 通过使用线性混合效应模型,在34名PMS患者,30名RRMS患者和30名HC患者中比较QPS诱导的皮质可塑性.
- 与QPS诱导的可塑性程度与运动和认知结果相关联.
- 研究了皮质脊柱管完整性对可塑性和功能的影响.
主要成果:
- 在HC和RRMS患者 (p=0.86) 或PMS患者 (p=0.18) 之间没有发现QPS诱导的皮质可塑性的显著差异.
- 塑性和运动/认知功能之间的相关性仅在皮质脊髓管完整性完整的患者中观察到.
- 探索性分析显示,皮质脊髓损伤患者的QPS诱导可塑性显著降低 (p<0.001).
结论:
- 对于QPS诱导的皮质可塑性及其在MS中的功能相关性而言,金字塔管的完整性比疾病亚型更为关键.
- 皮质脊柱管的完整性是影响皮质可塑性和多发性硬化症功能结果之间的关系的一个关键因素.
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