多发性硬化症老年人口的并发性疾病:丹麦全国性研究
Rolf Pringler Holm1, Malthe Faurschou Wandall-Holm1, Finn Sellebjerg2
1Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
Frontiers in neurology
|December 11, 2023
概括
患有多发性硬化症 (MS) 的老年人有更多的急性和慢性并发症,增加死亡风险. 管理这些并发症对于有效的多发性硬化症治疗策略至关重要.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种进展性神经退行性疾病.
- 患有多发性硬化症的老年人群面临着伴随疾病的风险增加.
- 伴随性疾病对MS进展和结果的影响需要进一步调查.
研究的目的:
- 与匹配的对照组相比,评估老年多发性硬化症患者的急性和慢性并发症.
- 调查慢性并发病对MS全因死亡率的影响.
主要方法:
- 使用丹麦多发性硬化病登记册进行全国范围的基于登记册的研究.
- 匹配的队列设计比较MS患者 (n=8,688) 与一般人口对照 (n=86,880).
- 慢性疾病的查尔森并发症指数;急性疾病的ICD-10代码;死亡率分析的考克斯回归.
主要成果:
- 多发性硬化症患者的急性住院率较高 (OR: 2.1) 和住院时间较长.
- 在MS患者中观察到慢性并发症负担显著增加 (p < 0.001).
- 慢性并发症 (查尔森评分≥4) 减轻了MS患者死亡风险的增加.
结论:
- 患有多发性硬化症的老年人患急性和慢性并发症的患病率更高.
- 慢性并发症显著增加了MS患者因任何原因死亡的风险.
- 对伴随性疾病的评估对于优化多发性硬化症的治疗和管理策略至关重要.
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