新兴趋势和热点 核因素与红色素2相关的2因子在神经系统疾病中的新兴趋势和热点
Xue-Qin Chang1, Ling Xu1, Yi-Xuan Zuo1
1Department of Neurology, Xinhua Hospital Affiliated with Dalian University, Dalian 116011, Liaoning Province, China.
World journal of clinical cases
|December 11, 2023
概括
关于神经疾病中核因素红色素2相关因子2 (NRF2) 的研究正在迅速扩大. 虽然中国在出版物方面处于领先地位,但美国在有影响力的研究方面处于领先地位,强调NRF2是关键的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 核因子红色素2相关因子2 (NRF2) 是一种转录因子,在神经疾病研究中具有重要意义.
- 现有的文献缺乏关于神经系统疾病中NRF2的研究热点和进化趋势的系统概述.
研究的目的:
- 在神经疾病中识别和分析NRF2的研究热点和演变模式.
- 探索这个快速发展的领域的未来研究趋势.
主要方法:
- 在2010年至2022年的Web of Science核心集合数据库上进行了全面的文献搜索.
- 关键词包括NRF2 (例如NFE2L2,NF-E2相关因子2) 和神经疾病 (例如大脑疾病,中枢神经系统疾病) 的各种术语.
- 数据分析和可视化使用Cite-Space软件进行.
主要成果:
- 总共分析了1884篇文章,自2015年以来出版物的数量大幅增加.
- 中国贡献的出版物最多,而美国的研究中心性和H指数更高.
- 关键的关键词包括"氧化应激"",NRF2"",激活"",表达"和"大脑".
结论:
- 关于NRF2在神经疾病中的作用的研究正在进行和扩大,NRF2显示出作为治疗点的潜力.
- 发达国家在有影响力的出版物方面处于领先地位,而中国在文章量方面处于领先地位.
- 尽管进行了广泛的研究,但对神经系统疾病中的NRF2的理解仍然有限,需要进一步研究.
更多相关视频
相关概念视频
NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
The Nucleolus
8.9K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.9K
Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Nuclear Export
3.7K
The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
3.7K


