对影响CA125水平的因素的观察性研究在绝经前妇女中
Amrita Balachandran1, S Radhakrishna Nayak1
1Department of Obstetrics and Gynecology, Kasturba Medical College, Mangalore, Karnataka, India.
Advanced biomedical research
|December 11, 2023
概括
在绝经前妇女的月经期间,癌症抗原125 (CA125) 水平较高. 诸如月经持续时间和咖啡因摄入等因素显著影响这些CA125水平.
科学领域:
- 妇科 妇科 妇科 妇科
- 临床化学 临床化学
- 生物标志物研究 生物标志物研究
背景情况:
- 在绝经前的妇女中,CA125水平在整个月经周期中表现出变化.
- 许多可修改和不可修改的因素影响CA125值,需要仔细解释.
- 了解这些变异对于准确的临床评估至关重要.
研究的目的:
- 在周期中期和月经阶段比较CA125水平.
- 确定影响生殖年龄妇女CA125值的人口和临床因素.
主要方法:
- 从2017年12月到2019年5月进行了一项观察性研究.
- 包括年龄在15-45岁的有规律月经周期的女性.
- 在周期中期和月经期之间比较CA125水平;回归分析确定了影响因素.
主要成果:
- 与月经周期中期 (12.39 ± 7.3) 相比,CA125水平在月经期间 (24.74 ± 17.43) 显著更高 (P < 0.0001).
- 多变量回归确定月经日 (P = 0.0001) 和定期摄入咖啡因 (P = 0.007) 是显著的积极风险因素.
- 参与者的平均年龄为28.71±6.14岁.
结论:
- 绝经前妇女在月经期间的CA125水平明显高于月经周期中期.
- 月经持续时间和咖啡因消费是与CA125水平升高相关的关键因素.
- 这些发现强调了在解释CA125结果时考虑月经周期阶段和生活方式因素的重要性.
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