周围过程性血栓发生变化与经过透气管大动脉植入的患者的亚临床传单血栓症进展有关
Naoto Kuyama1, Koichi Kaikita2, Masanobu Ishii1,3
1Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan.
Circulation reports
|December 11, 2023
概括
过导管大动脉植入术 (TAVI) 后的亚临床传单血栓症与T-TAS.测量的血栓性暂时降低有关. 监测这些变化可能有助于预测叶片血栓的进展.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- 亚临床传单血栓是通过导管的大动脉植入 (TAVI) 后的一个已知的并发症.
- 确切的原因和血栓发生性和TAVI后的叶片血栓形成之间的关系仍然不清楚.
研究的目的:
- 为了研究TAVI后的血栓性和亚临床叶片血栓症 (低衰减叶片加厚和最大叶片厚度) 之间的关系.
- 为了评估整个周围手术期间血栓生成参数和小册子形态的变化.
主要方法:
- 招募了35名接受TAVI治疗的患者.
- 使用全血栓形成分析系统 (T-TAS) 评估血栓性,测量PL18-AUC10和AR10-AUC30.
- 在TAVI后7天和3个月的CT扫描中,通过CT扫描评估了低衰减的叶片厚度 (HALT) 和最大叶片厚度 (MLT).
主要成果:
- 在TAVI后的2天和7天,T-TAS参数显示过渡性下降,改善了3个月.
- 在7天和3个月后,分别在20%和17%的患者中观察到HALT.
- 在TAVI后7天,AR10-AUC30降低和MLT增加之间发现了显著的正相关性,AR10-AUC30降低和D-二次数升高预测了MLT恶化.
结论:
- 在TAVI后暂时降低血栓发生率与小册子血栓症有关.
- 监测血栓发生率可以作为一个有价值的工具来预测在TAVI后的叶片血栓的进展.
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