巴西尔-卡尔梅特-格林调节人类巨细胞和树突细胞对SARS-CoV-2 S-糖蛋白的反应
Regina C Ambe1, Shubhang Bhalla1, Alejandra Alvarado1
1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
Infectious medicine
|December 11, 2023
概括
预暴露于Bacille Calmette-Guerin (BCG) 增强了免疫细胞对SARS-CoV-2 S-glycoprotein的反应. 这表明BCG诱导的训练免疫力可能会降低COVID-19的易感性和严重性.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 流行病学研究表明,Bacille Calmette-Guerin (BCG) 可能会提供对COVID-19的保护.
- 研究BCG对免疫细胞对SARS-CoV-2反应的影响对于了解潜在的治疗策略至关重要.
研究的目的:
- 为了确定BCG的预暴露是否能调节人类单细胞衍生的巨细胞和树突细胞对SARS-CoV-2 S-glycoprotein的反应.
- 探索BCG在对抗病毒感染的训练免疫力中的作用.
主要方法:
- THP-1细胞分化为巨细胞或树突细胞.
- 细胞被暴露在BCG中,随后被SARS-CoV-2 S-糖蛋白刺激.
- 测量了转录因子NF-κB和IRF的激活.
主要成果:
- 对BCG的预暴露在SARS-CoV-2S-葡萄糖蛋白刺激后显著增加了巨细胞和树突细胞中的IRF和NF-κB激活.
- BCG预暴露增强了炎症转录因子的激活,以应对病毒S-葡萄糖蛋白.
结论:
- 经过BCG预暴露,可以促进人体免疫细胞对SARS-CoV-2 S-glycoprotein的炎症反应.
- BCG诱导的训练免疫是一种减轻SARS-CoV-2感染和COVID-19严重性的潜在策略.
- 这些发现支持开发基于BCG的病毒感染疗法.
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