一个错过的突骨质状骨质变异症病例
Omar Alkhabbaz1, Yasser Bibi1, Brian Webb1,2
1Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, USA.
Cureus
|December 11, 2023
概括
突骨髓骨质疏松症是一种良性关节疾病,可以被误认为是骨关节炎. 早期诊断和手术干预,如突切除术,显著改善患者的结果和关节功能.
科学领域:
- 整形外科 整形外科 整形外科
- 病理学 病理学 病理学
- 放射学 放射学是一门学科.
背景情况:
- 突骨髓骨质疏松症 (SO) 是一种良性关节病理,涉及突膜中的软骨结节.
- 它通常影响大关节,并且可以呈现为关节疼痛,有时模仿其他疾病,如骨关节炎.
- 延迟诊断可能导致关节损伤,骨关节炎或罕见的恶性转变.
研究的目的:
- 为了呈现一种最初被误诊为骨关节炎的突骨髓骨质疏松症病例.
- 强调在关节疼痛的差异诊断中考虑SO的重要性,特别是在模两可的成像中.
- 要突出先进成像和组织病理学的诊断作用.
主要方法:
- 一个62岁的女性患有双侧膝关节疼痛的病例报告.
- 骨关节炎的初始诊断基于临床评估和X射线.
- 连续磁共振成像 (MRI) 扫描超过三年.
- 手术干预包括左膝关节主要突切除.
- 组织病理学证实了突骨髓骨质变质症.
主要成果:
- 患者的初始呈现和成像与骨关节炎一致.
- 随后的核磁共振扫描引起了对突骨质状骨质变质症的怀疑.
- 手术后的突切除术导致了显著的疼痛缓解,恢复了行走.
- 组织病理学证实了突骨髓骨质疏松症的诊断.
结论:
- 交尾骨髓骨质疏松症的诊断可能具有挑战性,并且可能最初被错误识别.
- 像MRI这样的高级成像对于将SO与其他关节病理区分开来至关重要.
- 及时的手术管理,如突切除术,可以带来出色的患者结果.
- 在患有持续关节疼痛的患者中,维持SO的高怀疑指数至关重要.
相关概念视频
01:07Development of the Limb Synovial Joints
1.4K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.4K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:24Bone Formation by Endochondral Ossification
4.5K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.5K
01:23Knee Joint
1.8K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.8K
01:10Ankle Joint
1.6K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.6K
01:27Growth of Cartilage and Bone Tissue
3.3K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.3K