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Updated: Jul 8, 2025

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对c-Met和c-Srcc的宏环抑制剂TPX-0022的结构洞察力

Lingzhi Qu1, Hang Lin1, Shuyan Dai1

  • 1Department of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Computational and structural biotechnology journal
|December 11, 2023
PubMed
概括

一种针对c-Met,c-Src和CSF1R激酶的新型抑制剂TPX-0022对各种癌症突变表现出强大的活性. 结构分析揭示了它的结合机制,为克服先进的固体瘤中抗药性提供了洞察力.

关键词:
这就是C-Met的意义.在C-Srccc.晶体结构 晶体结构对抗性相关的突变.TPX-002222 这是一个很好的方法.

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