在 ICAM1 HFpEF 风险变体和炎症生物标志物
Pedro Giro1, Kent D Taylor2, Sanjiv J Shah1
1Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
American heart journal plus : cardiology research and practice
|December 11, 2023
概括
ICAM1变种rs5491与炎症增加有关,特别是黑人人中高hsCRP和TNFR-1水平. 这一发现可能有助于解释其与心力衰竭与保存喷射分数 (HFpEF) 的关联.
科学领域:
- 遗传学 遗传学 是一个
- 心血管疾病 心血管疾病
- 免疫学 免疫学 免疫学
背景情况:
- ICAM1变种rs5491 (p.K56M) 在黑人群体中普遍存在,并与心力衰竭与保留射出分数 (HFpEF) 有关.
- 连接rs5491与HFpEF的生物机制尚不清楚.
研究的目的:
- 调查ICAM1变种rs5491与黑人个体炎症生物标志物之间的关联.
- 探索将rs5491与HFpEF联系起来的潜在途径.
主要方法:
- 对1558名来自多民族动脉样硬化研究的黑人参与者的分析.
- 评估rs5491变体与高灵敏性C反应蛋白 (hsCRP),IL-6 (IL-6) 和瘤亡因子-α受体1 (TNFR-1) 的水平之间的关联.
主要成果:
- 每个额外的rs5491等位基因都与明显更高的hsCRP (P=0.02) 和TNFR-1 (P=0.02) 水平有关.
- 在rs5491和IL-6水平 (P=0.29) 之间没有发现显著的关联.
- 尽管对hsCRP进行了调整,但rs5491和HFpEF之间的联系仍然很重要.
结论:
- 在黑人个体中,ICAM1变体rs5491与hsCRP和TNFR-1.1的升高有关.
- 这些炎症标志物可能会调解rs5491和HFpEF之间的关联.
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