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病例报告:平衡免疫反应 - 在恶性黑色素瘤的BRAF/MEK治疗下多发性硬化症疾病恶化
Katrin Pape1, Maria Protopapa1, Muriel Schraad1
1Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Frontiers in oncology
|December 11, 2023
概括
BRAF/MEK 抑制剂可以使黑色素瘤患者的多发性硬化症 (MS) 恶化. B细胞枯竭疗法稳定了MS,允许继续癌症治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- BRAF/MEK 抑制剂可以改善黑色素瘤无进展生存率.
- 这些抑制剂可以悖论地激活免疫细胞中的MAPK/ERK通路,可能加剧自身免疫性疾病.
- 患有先前存在的自身免疫性疾病的患者需要在此疗法期间进行仔细监测.
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