在研究导致子宫内膜癌的非编码RNA介导的昼夜节律障碍的最新进展
Ling-Tao Zheng1, Shao-Rong Chen1, Liang-Yu Zhou1
1Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Frontiers in oncology
|December 11, 2023
概括
与夜间工作相关的循环节律障碍 (CRD) 可能是子宫内膜癌 (EC) 的基础. 非编码RNAs (ncRNAs) 调节时钟基因,调解CRDs与EC发育之间的联系.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 分子生物学分子生物学
- 时间生物学 时间生物学
背景情况:
- 子宫内膜癌 (EC) 是一种流行的妇科恶性瘤.
- 确定的危险因素包括肥胖,代谢功能障碍和遗传倾向.
- 新出现的证据将昼夜节律障碍 (CRDs) 与EC严重程度联系在一起,这表明它在致病过程中发挥了作用.
研究的目的:
- 审查和综合目前关于EC,CRD和非编码RNA (ncRNA) 之间的关系的研究.
- 探索ncRNA介导CRDs作为一种促进EC发展的代谢途径的潜在作用.
主要方法:
- 对现有研究和报告进行全面的文献综述.
- 对涉及时钟基因 (CGs),ncRNAs和昼夜节律的调节网络的分析.
- 探索ncRNA介导的CRD和EC之间的机制联系.
主要成果:
- 通常与夜间工作等生活方式因素相关的CRDs越来越被认为是EC的潜在贡献者.
- 时钟基因 (CGs) 是昼夜节律的关键调节者.
- 非编码RNA (ncRNAs) 在调节CG表达和功能方面发挥着至关重要的作用,从而影响昼夜节律和潜在的EC发育.
结论:
- CRDs代表了与EC有合理的代谢联系.
- ncRNAs正在成为连接CRD与EC的途径中的关键调解者.
- 对ncRNA-CRD相互作用进行进一步的研究是有必要的,以阐明EC病原体和确定治疗点.
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