在患有直肠癌的患者中,增加C-反应蛋白和心血管疾病之间的关联
Huimin Qiao1,2, Changxin Wang3, Chunhong Yang4
1Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Frontiers in oncology
|December 11, 2023
概括
增加的C-反应蛋白 (CRP) 与直肠癌患者的心血管疾病 (CVD) 有关. 化疗进一步提高CRP,影响心血管疾病风险和预测.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 生物化学 生物化学
背景情况:
- 结直肠癌患者面临心血管疾病 (CVD) 的风险增加.
- C-反应蛋白 (CRP) 是一种已知的炎症标记物,可能与心血管疾病有关.
- 癌症治疗,特别是化疗对CRP水平和随后的心血管疾病风险的影响需要进一步调查.
研究的目的:
- 调查直肠癌患者中高C反应蛋白 (CRP) 和心血管疾病 (CVD) 之间的关联.
- 了解直肠癌化疗如何影响CRP水平.
- 探索驱动化疗诱导的CRP升高的潜在分子机制及其与心血管疾病的联系.
主要方法:
- 从2010年到2020年,对827名直肠癌患者进行了回顾性分析.
- 评估CRP水平与心血管疾病发病率之间的关系.
- 对化疗对CRP影响的定性评估,包括基因表达分析 (DEGs,GO,KEGG) 以确定调节机制.
主要成果:
- 在直肠癌患者中,发现CRP升高和心血管疾病事件之间存在显著的关联 (p < 0.01).
- 升高的CRP改善了心血管疾病模型的预测性能 (AUC为0.724对0.707).
- 化疗显著增加了治疗后的CRP水平 (p < 0.001),其中96个不同表达的基因与这种增加有关,以及与动脉样硬化相关的三个枢纽基因.
结论:
- 化疗后CRP水平升高与直肠癌患者的心血管疾病事件有显著的相关性.
- 在这种患者群体中,CRP作为预测心血管疾病风险的有价值生物标志物.
- 了解化疗诱导的CRP升高的机制,可以帮助对直肠癌幸存者进行心血管疾病风险管理.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
95
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
95
01:27Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
01:30Inflammatory Bowel Disease II: Crohn's Disease
253
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
253
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
01:17Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
188
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
188