最近的抗瘤疗法不会增加癌症患者的Omicron COVID-19严重程度:中国的一项两中心回顾性研究
Ying Liu1, Wenyao Zhu2, Zhiwu Wang3
1Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou, China.
Frontiers in oncology
|December 11, 2023
概括
包括化疗在内的抗癌疗法在Omicron大流行期间不会使癌症患者的COVID-19严重程度恶化. 瘤学家不应该停止癌症治疗,特别是对于轻度COVID-19症状的患者.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 抗癌疗法对癌症患者COVID-19严重性的影响在Omicron流行期间仍然不清楚.
- 中国的BA.5.2和BF.7欧米克朗菌株为研究瘤患者提供了独特的机会.
- 了解这些因素对于在病毒爆发期间管理癌症患者至关重要.
研究的目的:
- 为了确定抗癌治疗对癌症患者COVID-19严重性的影响在Omicron变种流行期间.
- 在这个人群中确定与COVID-19严重程度相关的临床因素和癌症特征.
- 为继续癌症治疗提供基于证据的建议.
主要方法:
- 一项涉及554名感染COVID-19的癌症患者的回顾性研究在中国的两个中心进行.
- 收集的数据包括抗癌治疗史和一般临床特征.
- 使用统一变量统计分析来识别与COVID-19严重程度相关的因素.
主要成果:
- 在554名患者中,2.7%患有严重/危急的COVID-19,15.5%患有中度严重,81.8%患有轻度严重.
- 高龄,男性性别,更差的ECOG分数,未接种疫苗的状态,以及先前存在的肝脏,脏或大脑疾病与COVID-19严重程度的增加相关.
- 最近的抗瘤治疗,包括在两周内进行的化疗,与COVID-19严重程度没有显著的相关性.
结论:
- 感染Omicron变种的癌症患者的COVID-19严重程度不会因最近的抗癌疗法而恶化.
- 这些患者不应停止抗癌治疗,特别是那些患有轻度COVID-19的患者.
- 这一发现支持在疫情期间继续提供必要的癌症治疗方法.
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