相关实验视频

Updated: Jul 8, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

在血液癌症中Trisenox的机制更新

Ananta¹, Swati Benerjee¹, Paul B Tchounwou²

¹Department of Life Sciences, School of Earth, Biological, and Environmental Sciences, Central University of South Bihar, Gaya, India.

Current research in pharmacology and drug discovery

|December 11, 2023

概括

三氧化物 (Trisenox) 通过准PML-RARα融合基因,有效地治疗急性肌肉细胞白血病 (APL). 本综述详细介绍了APL治疗和药物耐药性的机制和组合疗法.

科学领域:

血液学血液学血液学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

急性肌肉细胞白血病 (APL) 是一种急性肌肉细胞白血病 (AML) 的亚型,其特征是特定的染色体转位.
三氧化 (三氧化,ATO) 是APL的关键化疗剂,具有很高的疗效和生存率.

研究的目的:

审查Trisenox (TX/ATO) 在APL细胞中的最新作用机制.
总结关于涉及TX治疗急性白血病的组合疗法的信息.
为APL病理生理学和针对TX耐药APL的药物设计的研究人员提供见解.

主要方法:

在APL中对Trisenox (TX/ATO) 作用机制的文献综述.
分析TX对PML核体,蛋白质体降解,自,p53激活,端粒酶活性和信号通路的影响.
对急性白血病的组合治疗策略的审查.

主要成果:

TX通过多种机制抑制APL细胞的生长,包括PML核体的形成和蛋白质体的降解.
在具有PML-RARα融合基因的APL患者中,TX是有效的,但可以发生耐药性.
TX作用的机制包括p53激活,端粒酶调节和pRb/E2F异构.

结论:

TX是APL的关键治疗剂,通过多个分子途径起作用.
了解TX的机制对于开发针对TX耐药APL的策略至关重要.
组合疗法有望提高急性白血病的治疗结果.

关键词:

在APL中,细胞是APL细胞.这就是PML-RARα.这就是Trisenox.

更多相关视频

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Published on: December 16, 2022

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...