慢性肝病中反应性氧物种 (ROS) 介导的氧化应激及其通过药用植物的缓解

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Priyanka Sharma¹, Mukesh Nandave¹, Dipali Nandave²

¹Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University Pushp Vihar 10017, New Delhi, India.

American journal of translational research

|December 11, 2023

概括

反应性氧物种 (ROS) 对于细胞生存至关重要,但过度水平会导致肝损伤. 这篇评论探讨了氧化压力,它在慢性肝病中的作用,以及草药在治疗这些疾病中的潜力.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
肝病学肝病学是一种肝病学.

背景情况:

反应性氧物种 (ROS) 对细胞生存至关重要,低水平促进增殖,高水平诱导亡.
抗氧化剂维持的氧化还原稳定是细胞功能必不可少的,但破坏会导致氧化应激和潜在的肝损伤.
氧化应激会损害所有肝脏细胞类型,可能导致纤维化,细胞死亡和恶性转变.

研究的目的:

审查氧化应激及其指标在慢性肝病 (如酒精和非酒精脂肪肝疾病和肝炎) 中的作用.
评估ROS对脂质过氧化,铁,表观遗传修饰和肝损伤中的基因表达的影响.
突出传统草药作为治疗慢性肝病的潜在氧化还原调节剂.

主要方法:

文献综述侧重于肝病中的氧化应激机制.
分析ROS对细胞组件和表观遗传变化的影响.
探索传统草药在氧化还原调节中的作用.

主要成果:

氧化应激是慢性肝病的致病的一个重要因素.
ROS有助于脂质过氧化,铁和表观遗传变化,影响与细胞损伤相关的基因表达.
传统的草药显示出作为治疗药物治疗肝脏疾病中氧化还原失衡的希望.

结论:

氧化应激是导致慢性肝损伤的关键因素,影响细胞功能和表观遗传调节.
了解ROS介导的损害对于开发肝病有效治疗方法至关重要.
草药为管理氧化应激和改善慢性肝病的结果提供了潜在的途径.

关键词:

有反应性氧物种的反应性氧物种.酒精性肝病是一种肝病.草药是一种草药.氧化应激是一种氧化应激.

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