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听力皮层的间隙前脉冲抑制唤起了潜在的潜力,作为可能的客观声评估工具
Soheila Shayanmehr1, Nariman Rahbar2, Akram Pourbakht2
1Rehabilitation Research Center, Department of Audiology, School of Rehabilitation Sciences, International Campus, Iran University of Medical Sciences, Tehran, Iran.
这项研究表明,中前和左部区域的差距诱导抑制是评估耳的有希望的客观措施. 这种耳测试的最佳参数是在听力正常的受试者中确定的.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 临床神经生理学 临床神经生理学
背景情况:
- 主观的耳声评估缺乏客观性,导致变化.
- 需要一些客观的措施,比如对声震惊反射抑制的皮质记录.
- 声学惊反射的间隙前脉冲抑制 (GPI-ASR) 显示出作为客观耳测试的潜力.
研究的目的:
- 调查GPI-ASR作为一个客观的耳评估.
- 为了比较不同刺激参数 (间隙持续时间,间隙启动距离) 的间隙诱导抑制.
- 检查不同兴趣的脑区域 (ROI) 的抑制.
主要方法:
- 招募了20名没有听力损失或耳的参与者 (18-50岁).
- 声音刺激包括连续的噪音和一个惊的声音,先后有一个沉默的间隙.
- 使用27通道EEG记录皮质反应 (N1-P2复杂幅度,顶部图),分析了4个ROI.
主要成果:
- 在所有ROI中,最大GPI-ASR发生在40ms间隙持续时间和150ms间隙启动距离.
- 中正部和左部区域显示出最显著的抑制 (p<0.05).
- 在这些地区观察到N1和P2幅度的下降.
结论:
- 在所有测试参数和ROI中,GPI-ASR可以在正常人身上观察到.
- 在中前和左部区域的40-150毫秒参数产生了最大的抑制.
- GPI-ASR是一个有希望的,客观的工具来评估耳声,特别是对于儿童.
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