肠道微生物群及其功能代谢物与妇女产前抑郁症之间的关联
Tianqu Xie1, Xiaoxiao Fan1, Hanghang Pang1,2
1Center for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Neurobiology of stress
|December 11, 2023
概括
某些肠道细菌和短链脂肪酸 (SCFA) 与产前抑郁风险有关. 较低的血血清素 (5-HT) 也与增加的产前抑郁相关,这表明肠-大脑轴干预.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 孕产妇健康 孕产妇健康
背景情况:
- 肠道微生物群-大脑轴影响情绪.
- 产前抑郁症是一个重大问题.
- 了解肠道代谢物和神经递质的作用至关重要.
研究的目的:
- 研究肠道微生物群和短链脂肪酸 (SCFA) 对产前抑郁症的影响.
- 为了确定血5-西胺 (5-HT) 和产前抑郁症之间的关联.
- 探索肠道微生物群,SCFA,5-HT和产前抑郁症之间的相互作用.
主要方法:
- 招募了86名怀孕妇女在他们的第三个三个月.
- 使用爱丁堡分娩后抑郁症尺度评估产前抑郁症.
- 通过16S rRNA基因测序和SCFAs/5-HT通过质谱分析了肠道微生物群.
主要成果:
- 较高的 *Candidatus_Soleaferrea* 丰度与较低的产前抑郁风险相关.
- 增加酸度与更高的产前抑郁风险有关.
- 较低的血5-HT水平与增加产前抑郁风险有关.
结论:
- 肠道微生物群组成,SCFA水平和血5-HT与产前抑郁症有关.
- 研究结果表明,饮食或益生菌干预措施的潜力是针对肠-大脑轴在怀孕期间调节情绪.
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