基线和动态动脉硬状态与失脂症的关联:一个队列研究
Hai Wang1, Zhanhao Mo1, He Sui1
1China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China.
Frontiers in endocrinology
|December 11, 2023
概括
动脉硬度,通过手腕脚脉冲波速率 (baPWV) 测量,是发展失脂症的早期危险因素. 升高或增加的baPWV显著增加了一般人群中脱脂症发病的风险.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 脱脂症是动脉硬的已知原因之一.
- 动脉硬和失脂症发作之间的反向关系以前是未知的.
- 调查动脉硬性作为失脂症的预测因素对于心血管风险评估至关重要.
研究的目的:
- 为了检查基线动脉硬度及其变化与失脂血症发病率之间的关联.
- 为了确定动脉硬是否预测一般人口队列中的未来脱脂症.
- 探索动脉硬与脂质代谢之间的双向关系.
主要方法:
- 利用了北京健康管理队列 (2012-2019) 的数据.
- 采用了考克斯的比例回归模型来分析基线臂脉冲波速度 (baPWV) 和baPWV过渡.
- 与动脉硬度测量相关的评估事件失脂症.
主要成果:
- 总共有4362名参与者被分析,其中34.2%的人患有脂质失调症.
- 升高的基线动脉硬度 (baPWV) 与失脂症的风险增加有关 (HR 1.194).
- 与持续低baPWV相比,新发病和持续高baPWV显示出明显更高的脂质失调的过剩风险.
结论:
- 动脉硬度被确定为失脂症的早期危险因素.
- 这些发现表明动脉硬和脂质代谢之间存在双向关联.
- 动脉硬性可以作为缺脂症发展的预测标志物.
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