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在单个玻璃化加热芽细胞胚胎移植周期中预测正在进行的怀孕,开发和验证一个名录

Jae Kyun Park¹, Ji Eun Park¹, Soyoung Bang¹

¹Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea.

Frontiers in endocrinology

|December 11, 2023

概括

一种新型的诺姆图准确地预测了单个玻璃化加热芽细胞胚胎移植 (SVBT) 后的怀孕. 该工具使用母亲年龄,AMH,腺和胚胎因素来改善生育治疗的个性化预后.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
临床预测建模临床预测建模

背景情况:

全球越来越多地使用冷策略和单体玻璃化加热芽细胞胚胎移植 (SVBT).
在SVBT后准确预测临床怀孕至关重要,但由于缺乏精确的工具,这是具有挑战性的.
以患者为中心的护理需要可靠的方法来评估生育治疗的预后.

研究的目的:

开发和验证用于预测SVBT后正在进行的怀孕的诺姆图.
创建一个用户友好的工具,用于个性化的预后评估在辅助生殖技术.
通过定量数据分析,优化生育治疗决策的有效性.

主要方法:

对658名接受SVBT的患者进行了回顾性队列分析.
在临床共变量上使用多变量逻辑回归 (MLR) 开发名图.
随机分配患者进入培训 (n=461) 和验证 (n=197) 队列.

主要成果:

MLR确定了正在进行的怀孕的八个显著预测因素.
关键预测因素包括母亲的年龄,抗穆勒尔激素 (AMH),腺和胚胎参数 (形态,爆发日,重新扩张速度,胚胎链).
预测模型显示出良好的区分,在培训队列中,曲线下的面积 (AUC) 为0.675,在验证队列中为0.656.

结论:

一个个性化的名图作为预测SVBT结果的实用工具.
这种工具可以增强患者对生育治疗决策的理解和信心.
诺米图有助于临床医生提供准确和个性化的预后信息.

关键词:

在体外受精体外受精.这个名字是名ogramogram.正在进行的怀孕结果.预测模型预测模型单个玻璃化加热芽细胞胚胎转移胚胎

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