SEM:介绍细胞和组织建模中的机制,使用粗粒状同质粒子动力学
Sandipan Chattaraj1, Michele Torre2, Constanze Kalcher3
1Synthetic Physiology Lab, Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy.
APL bioengineering
|December 11, 2023
概括
我们开发了一个新的框架,亚细胞元素建模和力学 (SEM2),以建模工程组织的复杂力学. SEM2将细胞水平的行为与组织水平的变形结合在一起,推进有机体和器官在芯片上的研究.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 机械生物学 机械生物学
背景情况:
- 在工程组织中模拟多尺度机制是具有挑战性的,因为复杂的细胞行为.
- 亚细胞元件建模 (SEM) 捕捉了细胞的形学,但缺乏明确的多层次机制.
- 弥合细胞层面的动态和组织层面的变形对于理解工程组织至关重要.
研究的目的:
- 介绍一个新的计算框架,亚细胞元件建模和力学 (SEM2),用于多尺度组织建模.
- 将粒子级应力和应变分析纳入SEM,以解决现有模型的局限性.
- 展示SEM2在模拟细胞行为和工程组织中的机械特性方面的实用性.
主要方法:
- 通过将压力和应变分析集成到开源SEM++软件中,开发了SEM2.
- 应用SEM2来模拟单细胞的爬行,迁移和繁殖.
- 引入了一种新的力量来控制细胞迁移和增殖期间的核定位.
主要成果:
- SEM2成功地模拟了新兴细胞行为,并提供了对压力/应变分布的见解.
- 证明了框架能够模拟器官和芯片上的器官的扩散的能力.
- 通过第一原则文献价值和参数研究验证SEM2.
结论:
- SEM2为分析工程组织中的多尺度力学提供了一个强大的框架.
- 开发的模型增强了模拟细胞行为,如迁移和增殖.
- SEM2为设计和理解器官和芯片上的器官提供了有价值的工具.
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