营养不良的发病率和预后意义在早期多个系统缩
Shirong Li1,2, Lingyu Zhang1, Yanbing Hou1
1Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in nutrition
|December 11, 2023
概括
营养不良是多重系统缩 (MSA) 患者中常见的. 这种情况显著增加了死亡风险,突出了MSA患者早期营养支持的需要.
科学领域:
- 神经学 神经学
- 临床营养学 临床营养学
- 老年学是一门学科.
背景情况:
- 营养不良与各种疾病的生存率低下有关.
- 营养状况及其对多重系统缩 (MSA) 死亡率的影响仍未得到充分研究.
- 在MSA中营养不良的预后意义需要进一步调查.
研究的目的:
- 为了确定早期多重系统缩 (MSA) 患者营养不良的患病率.
- 评估营养不良的预后价值,以预测MSA中的死亡率.
- 通过控制营养状况 (CONUT) 评分和老年营养风险指数 (GNRI) 来评估营养状况.
主要方法:
- 招募了被诊断为早期MSA (疾病持续时间<3年) 的患者.
- 使用CONUT分数和GNRI评估营养状况.
- 使用卡普兰-梅尔生存分析和考克斯回归来分析预后价值.
主要成果:
- 与健康对照组相比,患有MSA的患者出现营养不良的患病率更高 (CONUT为44.6%,CONUT为14.1%,GNRI为17.9%,GNRI为0.9%).
- 营养不良的MSA患者的中位生存时间比正常营养的患者 (7.06年) 短 (5.98年) (p=0.012).
- 根据CONUT得分,营养不良与MSA (HR=1.556,p=0.030) 和MSA-P (HR=1.973,p=0.042) 的死亡风险增加有关.
结论:
- 营养不良在早期多重系统缩 (MSA) 中很普遍.
- 营养不良是MSA患者死亡的一个重要风险因素.
- 对于患有MSA的患者,应考虑早期营养干预.
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