埃蒂福克辛对健康男性肠道微生物群的短期影响
André Manook1, Thomas C Baghai1, Marco Riebel1
1Department of Psychiatry and Psychotherapy, Universität Regensburg, Regensburg, Germany.
Frontiers in neuroscience
|December 11, 2023
概括
在健康的男性中,埃提福克辛治疗减少了有益的肠道细菌,如Faecalibacterium duncaniae. 这种肠道微生物组的转变可能与增加的神经类固醇合成有关,这是情感障碍治疗的潜在因素.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经类固醇因其在情感障碍中的治疗潜力而越来越受认可.
- 埃蒂福克辛是一种已知的药物,可刺激内源性神经类固醇合成.
- 肠道微生物组在情绪障碍中的作用已经确立,但其与人类的etifoxine和神经类固醇的相互作用尚未被探索.
研究的目的:
- 调查埃蒂福克辛对人类肠道微生物群的影响.
- 探索etifoxine,神经类固醇合成和肠道微生物组成之间的潜在联系.
主要方法:
- 一个随机的,平衡的威廉姆斯交叉车设计研究,涉及36名健康的男性志愿者.
- 参与者接受了etifoxine,alprazolam或安慰剂为期5天的治疗期,分为9天的洗阶段.
- 使用高通量16S rRNA amplicon测序来分析便样本中的细菌组成.
主要成果:
- 在治疗之间没有观察到肠道微生物群α和β多样性的显著差异.
- 埃提福克素治疗导致了特定细菌物种的丰富性减少,包括Faecalibacterium duncaniae,Roseburia hominis和Lactobacillus rogosae.
- 这些减少的细菌物种被认为是健康肠道微生物组的有益组成部分.
结论:
- 这项研究代表了首次对肠道微生物组对短期etifoxine干预的反应进行人类调查.
- 虽然整体微生物群的多样性在很大程度上不受药物的影响,但etifoxine选择性地减少了某些有益细菌的丰富性.
- 观察到有益的肠道细菌的减少可能与etifoxine诱导的内源性神经类固醇水平升高有关.
关键词:
16S rRNA amplicon 序列的测序方式便细菌丹卡尼亚 (Faecalibacterium duncaniae) 是一种便细菌.在GABA-A传输过程中,罗兹布里亚人类 (Roseburia hominis) 是一种植物.威廉姆斯设计设计威廉姆斯设计埃蒂福克辛 (etifoxine) 是一种我们的肠道微生物组.这是神经类固醇.更多相关视频
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