白质连接体边缘密度的自闭症谱系障碍特异性变化基于功能定义的节点.
Clara F Weber1,2,3, Evelyn M R Lake1, Stefan P Haider1,4
1Yale University School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, United States.
Frontiers in neuroscience
|December 11, 2023
概括
早期自闭症谱系障碍 (ASD) 白质变化使用新的功能成像方法被确定. 这些发现强调了早期检测ASD相关大脑连接中障碍的潜力.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是大脑连接的中断.
- 了解白质 (WM) 微观结构变化对于早期发现ASD至关重要.
- 目前的方法可能无法完全捕捉早期,功能相关的连接体变化.
研究的目的:
- 应用一种新的方法,使用功能定义的节点来指导白质流体学.
- 为了识别与自闭症谱系障碍相关的微观结构连接体在整个生命周期中的变化.
- 为了比较功能引导与结构定义节点在检测ASD相关的WM变化的有效性.
主要方法:
- 利用来自自闭症研究国家数据库 (NDAR) 的扩散张力成像 (DTI) 数据,跨越多个年龄组 (婴儿到年轻人).
- 从fMRI研究中使用功能定义的皮质节点来指导WM路谱,创建边缘密度 (ED) 地图.
- 进行了基于声音和通道的分析,以评估ED和ASD诊断之间的群体差异和相关性.
主要成果:
- 在使用功能导向通道图 (p ≤ 0.001-0.483) 的婴儿中确定了与自闭症谱系障碍相关的显著变化.
- 使用与症状严重程度正相关的功能节点检测到与ASD相关的更广泛的差异.
- 沃克塞尔智能分析显示,ASD的幼儿,青少年和成年人中中央白质道的广泛减少.
结论:
- 在婴儿中检测到早期异常白质发育,后来被诊断为ASD,使用功能引导连接组映射.
- 功能引导的基于DTI的通道图比结构定义的节点对早期ASD相关的白质干扰更敏感.
- 结果强调了将功能信息纳入扩散成像和适应不同年龄组的协议的好处.
相关概念视频
01:19Autism Spectrum Disorder
100
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
100
01:30Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68