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艾滋病毒感染者的中枢神经系统和神经精神障碍

Nicolò Corti^1,2, Paolo Bonfanti^1,2

¹Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

Le infezioni in medicina

|December 11, 2023

概括

对于艾滋病毒感染者 (PLWH),基于BIC的治疗方案与基于DTG的治疗方案相比,显示了较少的中枢神经系统 (CNS) 和神经精神病 (NP) 症状. 这使得BIC成为改善PLWH生活质量的有吸引力的选择.

科学领域:

神经科学是一个神经科学.
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

中枢神经系统 (CNS) 和神经精神 (NP) 障碍在艾滋病毒感染者 (PLWH) 中普遍存在.
这些表现受到HIV直接对中枢神经系统的影响,抗逆转录病毒疗法 (ART),并发病症和与年龄相关的认知衰退的影响.
解决中枢神经系统/神经关节障碍对于改善PLWH人的生活质量至关重要.

研究的目的:

评估不同抗逆转录病毒疗法 (ART) 方案对PLWH中中枢神经/脑脊髓干扰的影响.
为了比较基于BIC和基于DTG的治疗方案关于中枢神经系统/中枢神经系统症状的耐受性概况.
为PLWH遇到中枢神经系统/中枢神经系统问题确定最佳的ART策略.

主要方法:

在不同ART疗法中对PLWH中中枢神经系统/中枢神经瘤症状发生率的比较分析.
对比基于BIC和基于DTG的治疗方案的研究的综述,对ART原始和病毒抑制的成年人进行比较.
评估患者报告的关于中枢神经/脑脊髓症状负担的结果.

主要成果:

基于BIC的疗法与基于DTG的疗法相比,与令人烦的中枢神经/脑脊髓症状的发生率相对较低.
这一发现适用于ART-naive和病毒学上被抑制的成年人群.
开发具有更好的中枢神经系统耐受性的少毒ART是持续进展的领域.

结论:

基于BIC的方案是管理PLWH中CNS/NP干扰的一个有希望的选择.
对于曾经接触过EFV或DTG并且报告中枢神经系统/中枢脑神经系统 (CNS/NP) 副作用的ART患者来说尤其有益.
未来ART的进展旨在获得具有最小毒性和增强中枢神经系统耐受性的分子.

关键词:

神经精神病学障碍神经精神疾病 PLWHWH 是一个字.杜洛特格拉维尔 (Dolutegravir) 是一种严重的药物.埃法维伦兹 (efavirenz) 是一种

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