消毒剂盖 in vitro 的有效性
Sara Giordana Rimoldi1, Leyla La Cava2, Chiara Palladino3
1Microbiology, Virology and Bioemergency Unit, ASST Fatebenefratelli Sacco, Milan, Italy.
Le infezioni in medicina
|December 11, 2023
概括
消毒剂盖 (DCs) 通过保持导管光线无菌性,有效地预防导管相关的血液感染 (CRBSIs). 两种测试品牌都显示出可比的疗效,支持它们在医疗机构的常规使用.
科学领域:
- 感染控制 感染控制
- 医疗器械的有效性 医疗器械的有效性
- 抗微生物技术 抗微生物技术
背景情况:
- 导管相关的血流感染 (CRBSI) 对住院患者构成重大风险.
- 消毒剂盖 (DC) 越来越多地被认为具有降低CRBSI率的潜力.
- 评估不同直流制造商的疗效对于预防感染的策略至关重要.
研究的目的:
- 来自两家制造商的消毒剂盖 (DC) 的体外消毒疗效评估.
- 为了比较这些DC在基线和应激条件下的有效性.
- 为了确定两个测试的直流产品之间是否存在显著差异.
主要方法:
- 一种体外模型被用来测试13种不同的微生物.
- 用无针连接器 (NFC) 上的直流器和直接在导管枢纽上评估了消毒剂的有效性.
- 在90分钟和180分钟的潜伏期后,评估了细菌生长.
主要成果:
- 两家DC制造商在14个测试中在基线测试中都表现出有效性.
- 在压力条件下,在特定时间点只观察到一种产品 (ICU MedicalTM) 的显著细菌负载 (Serratia marcescens).
- 另一种产品 (BD PureHubTM) 的MDRAcinetobacter baumannii细菌负载较低.
结论:
- 结果与BD PureHubTM的现有数据保持一致,并为ICU MedicalTM提供了新的见解.
- 在测试的两个DC品牌之间,没有发现有效性的显著差异.
- 支持与NFC配合的常规使用DC,以减少CRBSI发病率,作为综合感染控制包的一部分.
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