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下一代超基和多基物质:现状和趋势,水生有毒性和风险评估

Hannah Mahoney¹, Yuwei Xie¹, Markus Brinkmann^1,2,3,4

¹Toxicology Center, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5B3, Canada.

Eco-Environment & Health

|December 11, 2023

概括

新兴的聚和 perfluoroalkyl 物质 (PFAS) 如 PFECHS, 6:2 Cl-PFAES 和 HFPO-DA 构成环境风险. 研究表明不同的毒性潜力和数据缺口,需要对这些PFAS替代品进行进一步调查.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
化学品风险评估化学品风险评估

背景情况:

聚和 perfluoroalkyl 物质 (PFAS) 被广泛使用,导致环境无处不在和生物积累.
担心遗留PFAS的有毒影响导致禁令,但新兴的替代品正在进入市场.
关于这些替代PFAS的环境命运,运输和毒性的数据有限.

研究的目的:

为了审查和比较三个新兴的PFAS: perfluoroethylcyclohexane硫酸盐 (PFECHS), 6:2 化多甲基乙醇硫酸盐 (6:2 Cl-PFAES) 和六烯酸氧化物二元酸 (HFPO-DA).
评估它们的物理化学性质,环境命运,运输和与传统PFAS相比的毒性强度.
使用化学评分和排名模型量化危险,不确定性和数据差距.

主要方法:

对PFECHS, 6:2 Cl-PFAES和HFPO-DA的物理化学特性,环境命运和毒理学数据的文献综述.
化学评分和排名评估模型的应用.
新兴的PFAS与 perfluorooctane硫酸 (PFOS) 和 perfluorooctanoic酸 (PFOA) 的比较.

主要成果:

PFOS显示出最高的潜在毒性,其次是6:2Cl-PFAES,PFOA,HFPO-DA和PFECHS.
由于大量数据缺口,PFECHS和HFPO-DA显示了对未来研究的最大需求.
与PFOS和PFOA相比,对每个新出现的PFAS量化了相对的危险和不确定性.

结论:

像PFECHS, 6:2 Cl-PFAES和HFPO-DA这样的新兴PFAS由于其持久性和未知的毒性而存在潜在风险.
对于这些替代化学品,存在显著的数据缺口,突出显示需要进一步的研究.
持续出现的PFAS需要持续评估和监管,以保护环境和人类健康.

关键词:

对水生有毒性的水生毒性化学分数评分化学分数评分新出现的污染物新出现的污染物在PFAS中,有很多方法.替代的PFAS是可以替代的.

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