小脑对基于恐惧的情绪处理的贡献:对于理解自闭症中涉及的神经回路的相关性
Sabina Couto-Ovejero1, Jingjing Ye1, Peter C Kind1
1Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Frontiers in systems neuroscience
|December 11, 2023
概括
小脑传统上与运动有关,在处理恐惧和情绪反应方面发挥着关键作用. 了解小脑在恐惧处理中的功能,可能有助于了解自闭症情绪失调.
科学领域:
- 神经科学是一个神经科学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 传统上与感觉运动控制相关的小脑网络.
- 新出现的证据将小脑与非运动功能联系起来,包括基于恐惧的情绪处理.
- 大脑小脑在情绪中的作用涉及与各种大脑结构的相互作用.
研究的目的:
- 审查目前对小脑对恐惧处理的贡献的理解.
- 探索大脑小脑情感功能的解剖学,生理学和理论方面.
- 培养对自闭症情绪失调神经回路的洞察力.
主要方法:
- 关于小脑功能在恐惧调节中的现有文献的综述.
- 分析使用人类和非人类受试者的研究.
- 对小脑情绪处理的计算模型的检查.
主要成果:
- 小脑电路对于对威胁的有条件和无条件反应至关重要.
- 小脑参与恐惧记忆编码和存储.
- 假设的计算机制涉及内部模型和错误计算.
结论:
- 小脑异常与自闭症等神经发育障碍有关.
- 不典型的行为和焦虑在自闭症患者中很常见.
- 了解小脑恐惧处理对于解决自闭症情绪失调至关重要.
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