关于的可容忍上限摄入量水平的科学意见
EFSA journal. European Food Safety Authority
|December 11, 2023
概括
确定安全的摄入量对于预防神经毒性至关重要. 欧洲食品安全局 (EFSA) 专家小组建议成人每天摄入8毫克的安全摄入水平,因为由于数据不足,无法确定可容忍的上限摄入水平 (UL).
科学领域:
- 营养科学 营养科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 欧盟委员会 (EC) 要求就的可容忍上限摄入量 (UL) 发表科学意见.
- 评估了摄入量及其潜在的不良健康影响,特别是神经毒性.
研究的目的:
- 为了确定的可容忍上摄入水平 (UL).
- 评估通过饮食摄入引起的神经毒性的风险.
主要方法:
- 对人类和动物研究进行了系统的文献审查.
- 研究了诱导的神经毒性的剂量反应关系.
- 由于没有足够的数据来确定UL,使用了高消费者的估计背景饮食摄入量.
主要成果:
- 在现有研究中,神经毒性被支持为过多的摄入量的关键影响.
- 数据不足以描述剂量反应关系或为诱导的神经毒性建立参考点.
- 确定了安全摄入水平:成人 (≥18岁,包括孕妇和哺乳妇女) 每天8毫克,其他群体每天27毫克.
结论:
- 由于数据有限,无法确定的最终UL.
- 基于高背景饮食摄入量的安全摄入水平,提供了没有预期不良影响的摄入量指示.
- 确定的安全摄入水平具有局限性,因为它不定义有害影响的门值.
关键词:
UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL UL酸是一种酸.摄入的安全水平的摄入.可以容忍的上吸水水平.更多相关视频
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