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Updated: Jul 8, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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Chien-Hui Huang1, Sin-Yu Hou1, Scott Severance2

  • 1Department of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

ACS omega
|December 11, 2023
PubMed
概括

这项研究表明,内分循环[6.1.0]nonyne (BCN) 增强光在应变促进的亚酸循环添加 (SPAAC) 反应,与外分循环BCN不同. 这一发现使得新的光启动探针能够用于生物标志物活动检测.

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