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Updated: Jul 8, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Published on: October 15, 2017

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合成和评估Ivacaftor衍生品与降低的脂性

Melissa Iazzi1, Phillip Junor1, Jitesh Doshi2

  • 1Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario M5B 2K3, Canada.

ACS omega
|December 11, 2023
PubMed
概括

研究人员开发了 ivacaftor 的新型,低脂肪版本,以改善囊性纤维化 (CF) 治疗. 一种衍生品,化合物3,有效地恢复了CFTR通道功能,而不降低细胞表面蛋白质水平,与原始药物不同.

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