两种移植共聚合物Soluplus和Kollicoat IR的比较,作为通过不同的基于溶剂的方法制备的口服输送的arteether的固体分散载体
Parth Desai1, Bappaditya Chatterjee1,2
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, 400056 Mumbai, India.
ACS omega
|December 11, 2023
概括
使用Soluplus开发Arteether固体分散剂显著提高了其溶解性和溶解性. 这种配方为增强口服抗疟疾药物Arteether的生物可用性提供了一个有希望的方法.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 阿尔特以太 (ART) 是一种抗疟疾药物,口服生物利用性差 (BCS II类).
- 目前的临床管理涉及肌肉内注射基于油的溶液.
- 改善口服治疗对于患者的遵守和治疗疗效至关重要.
研究的目的:
- 为了提高Arteether的体外溶解和口服生物可用性.
- 为了研究使用Soluplus和Kollicoat IR.使用固体分散的潜力.
- 为了优化固体分散的配方和制备方法.
主要方法:
- 使用旋转蒸发,喷雾干燥和冷干燥来制备arteether固体分散物.
- 索鲁普卢斯和科利科亚特IR被用作各种药物-聚合物比率的聚合物载体.
- 评估了溶解性,溶解性和流动性.
- 内涂层囊被配制并测试了药物释放的情况.
主要成果:
- 喷雾干燥产生了最高的Arteether和溶解度 (476.01 mg/L在Soluplus 1:1),优于其他方法.
- 与Kolicoat IR.相比,Soluplus证明了作为固体分散载体的优越性能.
- 与原始ART (<10%) 相比,与ART-Soluplus (1:1) 的肠膜囊显著改善了药物释放 (88.88%).
结论:
- 索鲁普卢斯是一种有效的载体,可以创建具有增强溶解性和溶解性的Arteether固体分散物.
- 喷雾干燥是制备具有良好的流动性质的Arteether固体分散物的最佳方法.
- 开发出的稳定,部分无形的Arteether固体分散具有改善口服生物利用性的潜力.
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