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肠道微生物群和下呼吸道感染风险:一个双向的双样本孟德尔随机化研究

Wei Liu¹, Xinyan Wang¹, Ruizhi Feng¹

¹Division of Pulmonary Medicine, Department of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in microbiology

|December 11, 2023

概括

这项研究发现肠道微生物与下呼吸道感染 (LRTI) 之间没有强烈的因果关系. 虽然Blautia属显示出潜在的关联,但需要进一步的研究来确认其在LRTIs中的作用.

科学领域:

微生物组研究的研究.
传染病流行病学传染病流行病学
遗传流行病学遗传流行病学

背景情况:

观察性研究表明,肠道微生物群与下呼吸道感染 (LRTI) 之间存在联系.
这种关联的因果关系尚不清楚,需要进一步调查.

研究的目的:

调查肠道微生物群组成和发展LRTIs的风险之间的潜在因果关系.
使用双样本孟德尔随机化方法探索双向因果关系.

主要方法:

使用全基因组关联研究 (GWAS) 肠道微生物群和五种常见的LRTIs的总结统计数据进行了两样本的门德尔随机化 (MR) 分析.
用多种MR方法 (IVW,MR-Egger,加权中位数) 和灵敏度分析 (MR-PRESSO,异质性测试,留出一个) 来进行可靠的因果推断.
使用独立的LRTI GWAS数据集和CAUSE方法验证了结果.

主要成果:

预先的MR分析表明,肠道类Blautia对支气管和肺炎的几率增加的潜在因果作用.
然而,这些关联无法经受严格的统计纠正 (Bonferroni) 或 CAUSE 方法的验证.
反向MR分析没有显示LRTIs对肠道微生物群的持续性因果作用.

结论:

这项研究没有发现遗传预测的肠道微生物组与LRTI风险之间的因果关系的有力证据.
布劳蒂亚属需要进一步对其在呼吸道感染中的潜在作用进行物种或菌株水平的研究.

关键词:

蓝属 (Blautia) 是一个属属.门德尔的随机化这种因果关系是因果关系.我们的肠道微生物群.下呼吸道感染下呼吸道感染

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