在亨廷顿氏症和帕金森氏症中,亚体核显示了相反的功能连接模式
Stefania Evangelisti1,2,3, Sirius Boessenkool1,2, Chris Patrick Pflanz1,2,4
1FMRIB Centre, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK.
Brain communications
|December 11, 2023
概括
亨廷顿氏症和帕金森氏症在下丘脑核中表现出相反的静止状态功能连接,这是一个关键的基底质结构. 这一非侵入性发现将下体内核的变化与这两种疾病中的运动和认知症状联系起来.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 研究 研究 运动障碍
- 神经成像是一种神经成像.
背景情况:
- 亨廷顿氏病 (HD) 和帕金森氏病 (PD) 是不同的基底腺疾病.
- 亚thalamic核 (STN) 对于运动控制至关重要,但其在HD和PD中的in-vivo功能尚不清楚.
- 以前的研究通常需要侵入性方法来评估STN功能.
研究的目的:
- 在早期的HD和PD中,研究和比较亚thalamic核 (STN) 的休息状态功能连接 (rsFC).
- 为了确定STN是否在这两种运动障碍中表现出相反的功能特征.
- 为了将STN rsFC变化与临床症状严重程度相关联.
主要方法:
- 利用超高场7T核磁共振成像来进行高分辨率的全脑成像.
- 包括预先表现的HD携带者和早期PD患者,具有单边症状.
- 对24个健康对照进行了组对照相互作用分析.
主要成果:
- 与对照组相比,揭示了HD和PD对STN rsFC在传感运动网络中的差异性和相反的影响.
- 确定了特定疾病的STN连接性改变,包括PD中的深度大脑刺激"甜点".
- 在这两种疾病中发现了STN rsFC偏差的方向和大小以及运动/认知症状严重程度之间的关联.
结论:
- 首次非侵入性地证明了HD和PD病理生理学对STN功能连接的差异性和临床相关影响.
- 在HD和PD中突出了STN和感觉运动皮质的相反功能变化.
- 为这些运动障碍的共同和独特的神经生物学基础提供了新的见解.
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