在心力衰竭中存活的功能性心声决定因素与异常的喷射分数心力衰竭
Quirino Ciampi1, Lauro Cortigiani2, Nicola Gaibazzi3
1Cardiology Department, Fatebenefratelli Hospital of Benevento, Benevento, Italy.
Frontiers in cardiovascular medicine
|December 11, 2023
概括
冠状动脉流速 (CFV) 和冠状动脉流速储备 (CFVR) 预测了心力衰竭 (HF) 患者的存活率,减少了射出分数 (EF). 较高的CFV和较低的CFVR表明预后较差,独立于其他因素.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 心力衰竭 (HF) 随着左心室喷射分数 (EF) 的减少,预后异质.
- 在HF中预后的既定预测因素包括墙壁运动和EF.
- 使用冠状动脉流速 (CFV) 和冠状动脉流速储备 (CFVR) 的冠状动脉生理评估可以提供补充的预后信息.
研究的目的:
- 在心力衰竭 (HF) 和减少射出分数 (EF) 的患者中调查冠状动脉流速 (CFV) 和冠状动脉流速储量 (CFVR) 的预后值.
- 为了确定CFV和CFVR是否添加独立的预后信息,超出EF和诱导性缺血等既定的预测因素.
主要方法:
- 一项前性多中心研究,对1,408名高发烧患者进行,EF<50%.
- 基线CFV用脉冲波多普勒测量;CFVR用各种压力方法 (运动,多布他胺,血管扩展剂) 评估.
- 使用墙壁运动得分指数 (WMSI) 评估的诱导性缺血症和LV收缩储备 (LVCR).
- 主要终点是全因死亡,随访时间中位数为990天.
主要成果:
- 死亡的独立预测因素包括EF,CFV,CFVR,压力诱导的缺血症和LVCR.
- 较高的静止CFV (HR:2.407) 和较低的CFVR (HR:3.908) 与死亡率的增加显著相关.
- 综合这些参数的综合分数系统显示,最佳分数的死亡率最低 (1.2%),最低分数的死亡率最高 (31.9%).
结论:
- 高静止CFV与缺血性和非缺血性HF的生存率较差,EF降低.
- CFV提供预后信息是独立的和附加EF,CFVR,LVCR和诱导性缺血.
- 冠状动脉流速和储备是降低EF的HF患者风险分层的有价值工具.
关键词:
收缩性储备是指收缩性储备.冠状动脉的流量储备.扩大了心脏的mypothy.一个心脏的文件.基础设施资金来自意大利心电图和心血管成像公司 (SIECVI).出版 出版 出版 出版 出版压力回声 压力回声旅行旅行旅行旅行旅行旅行旅行更多相关视频
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