恩诺斯和MTHFR的基因多态度调节了汉族人口中孕前的发展
Jinghong Rao1, Youfang Chen2, Xuan Chen1
1Department of Obstetrics and Gynecology, Quanzhou First Hospital Affiliated to Fujian Medical University, No.250 East Street, Quanzhou 362000, Fujian, China.
Heliyon
|December 11, 2023
概括
内皮氧化合成酶 (eNOS) 和甲基基酸减少酶 (MTHFR) 基因的遗传变异与孕前风险有关. 特定的eNOS和MTHFR基因型与孕前患者的较低的氧化和较高的同类半氨酸水平有关.
科学领域:
- 遗传学 是一个遗传学.
- 产科 产科 产科 产科 产科
- 生物化学 生物化学
背景情况:
- 孕前 (PE) 是一个严重的妊娠并发症.
- 内皮氧化合成酶 (eNOS) 和甲基基酸减少酶 (MTHFR) 基因在血管功能和同类蛋白代谢中发挥作用,可能影响PE发展.
研究的目的:
- 调查eNOS基因多态性 (-786 T>C,894 G>T) 和MTHFR基因多态性 (1298 A>C,677 C>T) 与泉州孕前的相关性.
- 为了确定可靠的基因预测器,孕前.
主要方法:
- 病例控制研究涉及160名孕前患者和160名健康孕妇.
- 使用聚合酶链反应/限制片段长度多态 (PCR/RFLP) 的eNOS和MTHFR多态的基因定型.
- 测量氧化 (NO) 和同型半氨酸 (Hcy) 水平.
主要成果:
- 在eNOS 894 G>T和MTHFR 1298 A>C多态组之间没有发现显著的差异.
- 在PE患者中,eNOS -786 T等位基因和MTHFR 677 C等位基因的频率较低.
- 与eNOS -786 CC基因型的PE患者的NO水平较低,与MTHFR 677 TT基因型患者的Hcy水平较高.
结论:
- eNOS -786 CC基因型和MTHFR 677 TT基因型与孕前的风险增加有关.
- 这些基因型可能会通过减少氧化的产生和高水平的同类半氨酸促进孕前的发病.
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