低强度运动训练增加了心脏的缩功能和MHCII心脏居民巨细胞
Gang Wang1, Lin Wang1, Xuchao Wang1
1Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China.
Heliyon
|December 11, 2023
概括
低强度运动训练通过改变心脏居民巨细胞子集来改善心脏功能. 这种巨细胞的再分配,特别是MHCII低和MHCII高子集,可能有助于增强心血管健康.
科学领域:
- 心血管生理学心血管生理学
- 免疫学 免疫学 免疫学
- 运动科学 运动科学
背景情况:
- 身体活动通过很大程度上未知的机制有益于心血管健康.
- 心脏居民巨细胞 (cMacs) 和它们的子集调节心血管功能.
- 了解运动诱导的cMac变化是阐明心血管益处的关键.
研究的目的:
- 研究小鼠在低强度运动训练后cMac子集的动态变化.
- 阐明cMac子集再分配在运动诱导的心血管益处中的作用.
主要方法:
- 小鼠接受了为期五周的低强度跑步机跑步程序.
- 估计的体重,喷射率和心脏转录组.
- 分析了cMac子集,包括Ly6c-,MHCII低和MHCII高种群.
主要成果:
- 低强度运动抑制了体重增加和弹射率的增加.
- 运动改变了与肌肉收缩和线粒体功能有关的心脏基因表达.
- cMac分布转移,增加了MHCII低和减少了MHCII高子集,而没有改变总的Ly6c-cMacs.
结论:
- 低强度运动训练有益地重塑心脏居民巨细胞子集.
- cMac子集的重新分配,特别是MHCIIlow和MHCIIhigh,可能是心血管健康和射出小部分运动诱导的改善的基础.
相关概念视频
Exercise and Cardiovascular Response
825
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
825
Exercise and Cardiac Output
1.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.1K
Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K


