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利用CD44v6和V600EBRAF突变进行甲状腺癌的体外向组合治疗
A C L Mortensen1,2, J Imgenberg-Kreuz3, D Spiegelberg1,4
1Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
Heliyon
|December 11, 2023
概括
使用CD44v6抗体和索拉费尼布的向治疗对形甲状腺癌 (ATC) 有希望. 组合疗法显著损害了瘤球状体的生长,这表明分子放射治疗的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 放射疗法是一种放射治疗.
背景情况:
- 甲状腺癌对向治疗提出了挑战.
- 识别BRAF,EGFR和CD44v6等特定的分子标对于治疗开发至关重要.
- 现有的疗法有局限性,需要新的方法.
研究的目的:
- 评估针对甲状腺癌的向治疗的可行性.
- 探索BRAF,EGFR和CD44v6作为潜在的治疗点.
- 在临床前模型中评估新型向药物的疗效.
主要方法:
- 患者瘤样本 (n=22) 和细胞系的免疫组织化学和突变分析.
- 在不同的甲状腺癌亚型中评估CD44v6表达和BRAF突变.
- 在3D多细胞瘤球形中使用131I-AbN44v6和索拉芬尼的向治疗的评估.
主要成果:
- 在超过80%的甲状腺癌样本中,CD44v6过度表达,而EGFR表达是有限的.
- BRAF突变在乳头甲状腺癌中普遍存在,但在卵泡甲状腺癌中没有.
- 与131I-AbN44v6和索拉菲尼布的联合治疗显著抑制了形甲状腺癌球状体的生长.
结论:
- CD44v6是对形甲状腺癌分子放射治疗的有希望的标.
- 使用CD44v6的向治疗,无论是单独治疗还是与索拉芬尼结合,都显示出显著的潜力.
- 这项研究在体外提供了针对CD44v6的分子放射治疗的概念证明.
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