与非结核病患者相比,肺结核或脊柱结核病 (TB) 患者的大脑体积和厚度的差异:一个横截面的回顾性研究
Naif A Majrashi1, Abdullah H Khardali2, Hassan Aqeeli2
1Diagnostic Radiography Technology (DRT) Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Heliyon
|December 11, 2023
概括
肺结核或脊柱结核 (TB) 与大脑大小和厚度的减少有关. 这项研究强调了结核病患者的炎症生物标志物和大脑体积变化之间的联系.
科学领域:
- 神经成像是一种神经成像.
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 已知中枢神经系统结核病 (CNS-TB) 会导致各种神经疾病.
- 肺结核或脊髓结核对大脑形态学的影响仍然没有充分记录.
- 结核病与特定大脑区域炎症生物标志物升高有关.
研究的目的:
- 为了比较患有肺结核或脊柱结核的人与健康对照人之间的大脑体积和皮层厚度.
- 研究肺结核或脊柱结核患者的炎症生物标志物和大脑体积/厚度之间的关系.
主要方法:
- 磁共振成像 (MRI) 用于扫描23名肺结核患者和50名健康对照组 (18-65岁).
- 使用FreeSurfer软件量化了大脑体积和皮质厚度.
- 对在贾赞医院使用1.5TMRI扫描仪获取的数据进行了分析.
主要成果:
- 在结核病患者和对照人群之间观察到杏仁体,体,海马体,小脑和脑脊液 (CSF) 的体积有显著差异.
- 在结核病患者中,右侧心区域的厚度减少.
- 在结核病患者的炎症生物标志物 (CRP,WBC,血小板) 和大脑体积 (但不是厚度) 之间发现了显著的关联 (p <0.05).
结论:
- 这项研究首次证明,肺结核或脊柱结核可以导致大脑大小和厚度的减少.
- 这些发现表明,了解结核病可能会从探索炎症生物标志物和大脑体积变化之间的相关性中受益.
- 结核病影响大脑形态,强调神经成像在结核病患者管理中的重要性.
关键词:
大脑体积 大脑体积 大脑体积免费冲浪者 (FreeSurfer) 是一个自由冲浪者.炎症生物标志物 炎症生物标志物这就是为什么MRI是MRI.这就是为什么TBTBTBTB厚度 厚度 厚度 厚度皮质上皮质的皮层.更多相关视频
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