在高胆固醇血症患者中,阴茎粘膜相关微生物群的变化
Jia Li1,2, Jinxia Ma2, Weihua Wang2
1Department of Gastroenterology, The 983rd Hospital of Joint Logistic Support Force of PLA, No. 60, Huangwei Road, Hebei District, Tianjin 300142, China.
Heliyon
|December 11, 2023
概括
肠道微生物组的变化,特别是质粘膜微生物群,与高胆固醇血症有关. 某些细菌的数量较少,而其他细菌则较丰富,与胆固醇水平相关.
科学领域:
- 微生物学 微生物学
- 代谢疾病 代谢疾病
- 胃肠病学 胃肠病学
背景情况:
- 代谢性疾病通常与肠道微生物组的改变有关.
- 高胆固醇血症患者的粘膜微生物群的特定特征仍未得到充分研究.
研究的目的:
- 在患有高胆固醇血症的个体中,研究叶粘膜相关微生物群的组成和潜在功能.
- 为了确定与高胆固醇血症相关的特定微生物变化.
主要方法:
- 一项涉及13名高胆固醇血症患者和13名对照者的病例控制研究.
- 叶粘膜样本的16S rRNA基因测序.
- 生物信息分析包括β多样性和PICRUSt功能预测.
主要成果:
- 在高胆固醇血症和对照组之间观察到状粘膜微生物群组成的显著差异.
- 减少了Bacteroidetes,Bacteroides和其他属的丰富性;在高胆固醇血症患者中丰富了Anaerovibrio.
- 细菌菌类的丰富度与总和LDL胆固醇有负相关性;Coprococcus的丰富度与甘油三和BMI有负相关性.
- 高胆固醇血症组的丰富途径包括甘油脂代谢,ABC载体和与大肠杆菌相关的途径.
结论:
- 在高胆固醇血症患者中,皮质粘膜微生物群的组成有显著差异.
- 特定的细菌种群和功能途径可能在高胆固醇血症的发展或进展中发挥作用.
- 需要进一步的研究来探索因果关系和治疗潜力.
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