自主干细胞移植前后多发性髓瘤患者实验室指数的变化 自主干细胞移植前后
Rui Zhao1, Jing Zhao1, Yichuan Song1
1Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Journal of inflammation research
|December 11, 2023
概括
简单的实验室测试可以预测干细胞移植后多发性髓瘤的进展. 移植前低单细胞计数和炎症标志物,移植后高中性粒细胞和淋巴细胞计数,表明结果更好.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床化学 临床化学
背景情况:
- 新诊断的多发性髓瘤 (NDMM) 自主干细胞移植 (ASCT) 后的结果是可变的.
- 预测性标记物是必要的,因为当前的测试是侵入性的和昂贵的.
研究的目的:
- 确定实验室指标,预测在接受ASCT的NDMM患者的疾病进展.
- 分析移植前和移植后的实验室数据以预后价值.
主要方法:
- 在ASCT后的第5天和第90天收集完整血清 (CBC),生物化学和免疫学数据.
- 使用接收器运行特征 (ROC) 曲线来确定无进展生存 (PFS) 的截止值.
- 对166名接受ASCT的NDMM患者进行了单变量和多变量分析.
主要成果:
- 在ASCT前 (-5日):低绝对单细胞计数 (AMC),低全身炎症反应指数 (SIRI),低血清和低白蛋白预测优异PFS.
- 后ASCT (90日+): 绝对中性粒细胞数量高 (ANC),高的淋巴细胞与单细胞比率 (LMR),低的中性粒细胞与淋巴细胞比率 (NLR) 和低的SIRI预测了优越的PFS.
结论:
- 周围白细胞计数 (WBCC) 的炎症相关指标,包括ANC,NLR,SIRI和LMR,是潜在的生物标志物.
- 这些生物标志物可以预测在接受ASCT的NDMM患者中PFS,为当前方法提供一种不那么侵入性的替代方案.
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