管理HBV和HCV感染 肝移植前后的治疗
Naveen Kumar1, Narendra S Choudhary2
1Hepatology and Gastroenterology, Narayana Hospital Delhi, India.
Journal of clinical and experimental hepatology
|December 11, 2023
概括
B型肝炎和C型肝炎是导致肝衰竭的主要原因. 本综述涵盖了肝移植前和之后的乙型肝炎和型肝炎病毒感染的治疗方法,重点关注核类同类药物和直接作用抗病毒药物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 移植医学 移植医学
背景情况:
- 乙型肝炎 (HBV) 和乙型肝炎 (HCV) 是末期肝病和肝移植指示的主要驱动因素.
- 预防移植后的HBV复发对于长期的结果至关重要.
研究的目的:
- 对肝移植候选人和接受者的HBV和HCV感染的当前治疗策略进行审查.
- 突出抗病毒疗法的演变及其对患者管理的影响.
主要方法:
- 审查关于HBV和HCV治疗方案的现有文献.
- 讨论用于HBV的核类型和用于HCV的直接作用抗病毒药物的讨论.
- 与肝移植相比,治疗时间的分析.
主要成果:
- 核类型是移植前和移植后HBV管理的标准.
- 直接作用的抗病毒药物彻底改变了HCV治疗,实现了高持续的病毒学反应率 (高达90%).
- 对于晚期的HCV肝硬化,移植之后的抗病毒治疗通常是首选的.
结论:
- 有效的抗病毒疗法显著改善了接受肝移植的HBV和HCV患者的治疗结果.
- 管理策略必须根据特定的肝炎病毒和患者的临床状态量身定制.
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