较大的深白质高强度体积与亚急性缺血性中风患者的更严重的社会行为变化相关
Jian-Feng Qu1,2, Hui-Hong Hu3, Jian-Fei Liu1,4
1Department of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, China.
Frontiers in aging neuroscience
|December 11, 2023
概括
缺血性中风后的社会行为变化与深白质超强度 (WMH) 和功能结果有关. 较大的深层WMH体积和较差的修改兰金尺度 (mRS) 评分与中风患者的缺陷行为变化相关.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 行为科学 行为科学
背景情况:
- 缺血性中风可能导致社会行为的显著改变.
- 了解这些行为变化的神经生物学基础对于患者的康复至关重要.
研究的目的:
- 为了研究神经成像变量和亚急性缺血性中风患者的社会行为变化之间的相关性.
- 为了确定与中风后行为缺陷相关的特定神经成像标记.
主要方法:
- 首次缺血性中风患者的潜在查.
- 在中风后三个月使用前额行为清单 (FBI) 评估社会行为.
- 大脑MRI分析,包括急性心脏病发作和大脑结构体积,与行为数据相关联.
主要成果:
- 缺陷行为变化与左皮质梗塞,较高的胆固醇途径高强度度量表得分,深白质高强度量 (DWMH) 量以及修改的兰金度量表 (mRS) 得分有关.
- 在回归模型中,DWMH体积和随访mRS得分与赤字行为变化有显著的相关性 (R2=0.245).
结论:
- 增加深白质超强度 (WMH) 量是缺陷行为变化的重要预测因素.
- 较低的功能结果,由较高的mRS分数表明,也与缺陷的社会行为在缺血性中风后.
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