沙门氏菌的抗菌耐药性和基因组特征来自山东省的 brojlers
Liyuan Zhao1,2, Gang Liu1, Wenli Tang2
1College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Frontiers in veterinary science
|December 11, 2023
概括
耐多药沙门氏菌株对公众健康构成重大威胁. 这项研究在来自中国的沙门氏菌分离物中发现了高耐药率和众多抗菌耐药基因,需要紧急的控制策略.
科学领域:
- 通过食物传播的病原体.
- 抗微生物耐药性 抗微生物耐药性
- 基因组学就是基因组学.
背景情况:
- 沙门氏菌是一种引起全球公共卫生关注的动物性病原体.
- 多药耐药 (MDR) 沙门氏菌株的出现需要持续的监测和表征.
研究的目的:
- 调查MDR沙门氏菌株在中国山东省的流行情况.
- 描述抗微生物耐药性基因 (ARG),等离子体载体,血清型和孤立沙门氏菌株的遗传关系.
主要方法:
- 从947个样本中分离出167个沙门氏菌株,分别来自肉养殖场,屠宰场和市场.
- 抗生素敏感性测试和全基因组测序 (WGS) 用于血型定型,ARG检测,1类整子流行,等离子体分析和多位序列类型定型 (MLST).
主要成果:
- 91.0%的分离物是MDR,对安培,硫甲醇和纳利迪克酸具有很高的耐药性. 抗四环素耐药性基因tet(A) 是最常见的.
- 最常见的是IncX1等离子体 (74.3%),62.9%携带的是1类整体. 沙门氏菌是主要的血清,ST11是主要的序列类型.
- 观察到沙门氏菌的长途传播,南印第安纳州和南肯塔基州的沙门氏菌对西普罗夫洛克萨和第三代胞素具有很高的耐药性.
结论:
- 沙门氏菌的MDR菌株和相关的ARG构成了重大挑战.
- 需要紧急实施控制策略,以减轻与MDR沙门氏菌相关的公共卫生风险.
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