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创伤后应激障碍的5-MeO-DMT:一个现实世界的纵向病例研究

Anya Ragnhildstveit^1,2, Ryan Khan¹, Paul Seli^1,3

¹Integrated Research Literacy Group, Draper, UT, United States.

Frontiers in psychiatry

|December 11, 2023

概括

这项案例研究表明,5-甲基-N,N-二甲基三胺 (5-MeO-DMT) 可能有效治疗慢性创伤后应激障碍 (PTSD). 一次剂量为一个患者提供了持续的症状缓解和降低了自杀风险.

科学领域:

精神病学和翻译科学
药理学和药物发现

背景情况:

迷幻疗法是精神病治疗的新兴前沿.
5-甲基-N,N-二甲基三胺 (5-MeO-DMT) 是一种强大的血清刺激性迷幻药,具有治疗潜力.
有限的研究存在于5-MeO-DMT治疗创伤相关疾病,如PTSD.

研究的目的:

介绍5MeO-DMT用于慢性,耐治疗的PTSD的第一个纵向案例研究.
评估5-MeO-DMT在患有严重PTSD的患者中的安全性和有效性.

主要方法:

一次剂量蒸发的布福托克辛 (含有10-15毫克的5-MeO-DMT) 给了一名患有慢性PTSD的23岁女性.
对PTSD症状,绝望和自杀风险的临床评估在基线和治疗后1,3,6和12个月进行.
记录了患者报告的神秘体验和不良事件.

主要成果:

患者在治疗后立即经历了PTSD症状的显著,临床上有意义的改善,并在12个月内维持了这些收益.
观察到绝望和自杀风险明显减少.
患者报告说完全的神秘体验,没有严重的不良事件,尽管发生了急性恶心和夜间恐怖.

结论:

在这种情况下,5-MeO-DMT似乎是一种一般可容忍,安全和有效的治疗慢性耐火性PTSD.
治疗效果可能与报告的神秘体验有关.
由于案例研究的局限性,需要进一步的研究来证实这些初步发现.

关键词:

5-MeO-DMT的使用方法 5 - 甲基-NN 的使用.N-二甲基三胺的使用.创伤后应激障碍 (PTSD) 是一种案例报告案例报告创伤后应激障碍创伤后应激障碍迷幻疗法是一种心理治疗.创伤的创伤创伤的创伤.

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